|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
With in situ hybridization, a stronger expression of CaCC1 mRNA was further detected throughout the bronchial tissues from patients with asthma than control subjects (P<0.01); Samples from asthmatics were showed a stronger staining for MUC5AC than those in control subjects (P<0.05); AB-PAS staining revealed more mucins and goblet cells in asthmatic bronchial epithelium and submucosal gland comparing to that in control subjects (P<0.05).
|
17698377 |
2007 |
|
Colorectal Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
We finally established a five-gene signature (kinesin family member 15, N-acetyltransferase 2, glutathione peroxidase 3, secretogranin II, and chloride channel accessory 1) with prognostic value in CRC by step multivariate Cox regression analysis.
|
30132881 |
2019 |
|
von Willebrand Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
We also characterized a second, more catalytically active, N-terminal product of CLCA1, encompassing the catalytic domain together with its von Willebrand domain type A (VWA).
|
31570526 |
2019 |
|
Chronic Obstructive Airway Disease
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Using immunostaining with an anti-CLCA1 antibody, semi-quantitative image analyses of airway epithelium demonstrated significantly increased CLCA1 expression in smokers without COPD (p = 0.02) and in COPD patients (p = 0.002) compared with non-smokers.
|
22731784 |
2012 |
|
Respiratory Syncytial Virus Infections
|
0.020 |
AlteredExpression
|
group |
BEFREE |
To demonstrate a causative link, we depleted TLR3-/- mice of IL-13 during RSV infection and found that mucus and gob5 expression in the lungs was attenuated.
|
16424225 |
2006 |
|
Colorectal Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
Thus, CEACAM7, SLC4A4, GCG and CLCA1 may be prognostic markers or therapeutic targets of CRC.
|
31612015 |
2019 |
|
Intestinal Obstruction
|
0.010 |
Biomarker
|
disease |
BEFREE |
This suggests that CLCA1 has similar important functions in CF-related intestinal obstruction in humans as in Cftr-/- mice.
|
20179644 |
2010 |
|
Cystic Fibrosis
|
0.070 |
Biomarker
|
disease |
BEFREE |
This suggests that CLCA1 has similar important functions in CF-related intestinal obstruction in humans as in Cftr-/- mice.
|
20179644 |
2010 |
|
Cystic Fibrosis
|
0.070 |
Biomarker
|
disease |
BEFREE |
They warrant evaluation of CLCA1 blockers as adjunctive therapy in this condition and describe a simple model to evaluate therapeutic interventions for steroid resistant mucus, a common condition in patients with chronic lung disease like asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis.
|
31333624 |
2019 |
|
Chronic Obstructive Airway Disease
|
0.030 |
Biomarker
|
disease |
BEFREE |
They warrant evaluation of CLCA1 blockers as adjunctive therapy in this condition and describe a simple model to evaluate therapeutic interventions for steroid resistant mucus, a common condition in patients with chronic lung disease like asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis.
|
31333624 |
2019 |
|
Chronic lung disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
They warrant evaluation of CLCA1 blockers as adjunctive therapy in this condition and describe a simple model to evaluate therapeutic interventions for steroid resistant mucus, a common condition in patients with chronic lung disease like asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis.
|
31333624 |
2019 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that adenosine cooperates with inflammatory cytokines to stimulate mucin production in the asthmatic airway and supports the use of A1, CLCA1, and EGFR inhibitors in the treatment of asthma.
|
15345696 |
2004 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that CaCC1 plays a direct role in mucus production and differentiation in goblet cells and may contribute to the pathogenesis of asthma through its mucus-inducing activity.
|
11956057 |
2002 |
|
Cystic Fibrosis
|
0.070 |
Biomarker
|
disease |
BEFREE |
These findings suggest that human CLCA1 mediates a Ca2+-activated Cl- conductance in the human intestine and make it an interesting candidate as a modulating factor in the pathogenesis of cystic fibrosis.
|
9828122 |
1998 |
|
Malignant tumor of colon
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings suggest that CLCA1 and CLCA2 are potential prognostic biomarkers for patients with colon cancer.
|
31404307 |
2019 |
|
Colon Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings suggest that CLCA1 and CLCA2 are potential prognostic biomarkers for patients with colon cancer.
|
31404307 |
2019 |
|
Cystic Fibrosis
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
Therefore the role of hCLCA1 as a mediator of mucus overexpression in CF has to be questioned.
|
20542744 |
2010 |
|
Colorectal Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
The upregulation of karyopherin α 2 (KPNA2) and chromosome segregation 1‑like (CSE1L) in colorectal carcinoma, in addition to downregulation of chloride channel accessory 1 (CLCA1), fatty acid binding protein 1 (FABP1), sodium channel, voltage gated, type VII α subunit (SCN7A) and solute carrier family 26 (anion exchanger), member 3 (SLC26A3) was confirmed.
|
27121919 |
2016 |
|
Malignant Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
The source of the data was The Cancer Genome Atlas, and it was identified that high expression levels of CLCA1 and CLCA2 were associated with a favorable overall survival (OS) time in patients with colon cancer.
|
31404307 |
2019 |
|
Primary malignant neoplasm
|
0.030 |
AlteredExpression
|
group |
BEFREE |
The source of the data was The Cancer Genome Atlas, and it was identified that high expression levels of CLCA1 and CLCA2 were associated with a favorable overall survival (OS) time in patients with colon cancer.
|
31404307 |
2019 |
|
Respiration Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
The secreted airway mucus cell protein chloride channel regulator, calcium-activated 1, CLCA1, plays a role in inflammatory respiratory diseases via as yet unidentified pathways.
|
29610986 |
2018 |
|
Cystic Fibrosis
|
0.070 |
Biomarker
|
disease |
BEFREE |
The results suggest that pCLCA1 shares essential characteristics of hCLCA1, supporting the pig model as a promising tool for studying the modulating role of pCLCA1 in the complex pathology of CF.
|
19755716 |
2009 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The human hCLCA1 and murine mCLCA3 (chloride channels, calcium-activated) have recently been identified as promising therapeutic targets in asthma.
|
15879574 |
2005 |
|
Hepatic Encephalopathy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The genetic analyses showed that glutaminase TACC and CACC haplotypes were linked to the risk for overt hepatic encephalopathy.
|
20820037 |
2010 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The data demonstrated the up-regulated TFs such as GATA-3, AP4, c-Myc and Pbx1 in the gastric mucosa of GC patients compared with the healthy volunteers, while other TFs, particularly CCAAT and CACC, showed the consistently decreasing trend along the gastric carcinogenesis.
|
26563475 |
2015 |